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Dr. Reddy's subsidiary, Aurigene Oncology, has shown positive results in its Phase 1 clinical trial for blood cancer therapy, with 62.5% of patients achieving a complete response. This marks a significant step forward in cancer treatment.
Aurigene Oncology Limited, a subsidiary of Dr. Reddy’s Laboratories, has reported positive results from its first clinical trial of Ribrecabtagene autoleucel (DRL-1801), a new CAR-T cell therapy for multiple myeloma, a type of blood cancer. This breakthrough in cancer treatment marks a significant milestone as it is the first trial of its kind in India to test CAR-T therapy for this condition.
The Phase 1 clinical trial, named the SWASTH study, involved eight patients who had previously undergone multiple treatments for multiple myeloma, with an average of 5.5 prior treatments, including transplants. The trial yielded remarkable results, with all eight patients showing a clinical response to the therapy. Notably, 62.5% of these patients achieved a complete response, demonstrating the potential effectiveness of this new treatment.
Moreover, the therapy exhibited a strong safety profile. None of the patients experienced serious side effects, such as Cytokine Release Syndrome (CRS) or neurotoxicity, which are common concerns in CAR-T cell therapies. These results provide a solid foundation for further research and development.
Following the promising results of the Phase 1 trial, the Drugs Controller General of India (DCGI) has approved the initiation of Phase 2 of the trial, which will involve a larger cohort of patients. This advancement is expected to further evaluate the effectiveness and safety of Ribrecabtagene autoleucel in treating relapsed refractory multiple myeloma patients.
The trial results were recently presented at the 21st annual meeting of the International Myeloma Society in Rio De Janeiro, Brazil, showcasing India’s growing contributions to global cancer research.
With these positive trial outcomes, Aurigene Oncology’s efforts mark a significant advancement in blood cancer treatment. The success of the trial is likely to bolster investor confidence, potentially benefiting Dr. Reddy share price as the company continues its efforts in developing innovative cancer therapies.
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